What are the risk factors for thrombotic thrombocytopenic purpura?

Multiple organs are damaged due to thromboemboli blocking the blood vessels that are due to hemolytic anemia of microangiopathic type and thrombocytopenia. Kidney and CNS are the two main targets of vasoocclusive damage from this disease. Major risk factors of TTP include:

1. Pregnancy

2. Oral contraceptives use

3. Systemic lupus erythematosus (autoimmune condition)

4. Scleroderma (autoimmune condition)
5. Hematopoietic stem cell transplant

6. AIDS

7. HIV infection

8. Antiphospholipid antibody syndrome (autoimmune condition)

and use of drugs such as

9. Mitomycin C 

10. Gemcitabine

11. Bleomycin

12. Cisplatin

13. Tacrolimus 

14. Cyclosporine

15. Quinine (immune)

16. Quinidine (immune)

17. Ticlopidine (immune)

18. Clopidogrel (immune)

19. ADAMTS13 mutation

 By Doctor

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